Journal
JOURNAL OF MEDICAL VIROLOGY
Volume 78, Issue 4, Pages 514-516Publisher
WILEY-LISS
DOI: 10.1002/jmv.20570
Keywords
immunodeficient patient; valaciclovir prophylaxis; PCR
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Two cases of varicella zoster virus (VZV) meningitis are described in an 18-year-old girl and an 18-year-old boy. They occurred, respectively, 9 days and 9 months after allogeneic bone marrow transplantation. VZV nucleic acid was detected in the cerebrospinal fluid during the 1st week of illness. This recurrence occured despite valaciclovir prophylaxis and without skin lesions. The two patients received aciclovir intravenously and immunoglobulins infusion. They responded to treatment and their clinical state improved rapidly.
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