Journal
JOURNAL OF ANTIBIOTICS
Volume 59, Issue 4, Pages 248-250Publisher
JAPAN ANTIBIOTICS RESEARCH ASSOC
DOI: 10.1038/ja.2006.35
Keywords
marine-derived fungus Pseudallescheria; dehydroxybisdethiobis(methylthio)gliotoxin; bisdethiobis(methylthio)gliotoxin; gliotoxin; antibacterial activity; radical scavenging activity
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A new antibacterial dioxopiperazine, dehydroxybisdethiobis(methylthio)gliotoxin (1), and the previously described bisdethiobis(methylthio)gliotoxin (2) and gliotoxin (3), have been isolated from the broth of a marine-derived fungus of the genus Pseudallescheria. The structure and absolute stereochemistry of the new compound was assigned on the basis of NMR and CD experiments. Compounds 1 similar to 3 exhibit potent antibacterial activity against the methicillin-resistant and multidrug-resistant Staphylococcus aureus with MIC values of 31.2, 31.2, and 1.0 mu g/ml, respectively. Compound 3 also exhibited a significant radical scavenging activity against 1,1-diphenyl-2-picrylhydrazyl (DPPH) with IC50 value of 5.2 mu M.
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