Journal
INTERNATIONAL JOURNAL OF DEVELOPMENTAL NEUROSCIENCE
Volume 24, Issue 2-3, Pages 103-111Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.ijdevneu.2005.11.013
Keywords
cytoplasmic dynein; dynactin; axonal transport; microtubule motor proteins; motor neuron disease; neurodegeneration; amyotrophic lateral sclerosis
Categories
Funding
- NIA NIH HHS [T32 AG00255] Funding Source: Medline
- NIGMS NIH HHS [GM48661] Funding Source: Medline
Ask authors/readers for more resources
The microtubule motor protein cytoplasmic dynein and its activator dynactin are essential in higher eukaryotes, due to critical roles in vesicular transport and cell division. Neurons are uniquely sensitive to defects in dynein/dynactin function, which affect retrograde axonal transport, neurotrophic factor signaling, neurofilament transport, mRNA localization, neuronal migration, and protein recycling and degradation. Mutations in either dynein or dynactin lead to motor neuron degeneration and loss. Recent progress in understanding the cellular mechanisms of dynein/dynactin function, and the effects of dynein/dynactin dysfunction has provided new insight into the roles of microtubule-based motility in the neuron. (c) 2005 ISDN. Published by Elsevier Ltd. All rights reserved.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available