Journal
CURRENT OPINION IN IMMUNOLOGY
Volume 18, Issue 2, Pages 164-174Publisher
CURRENT BIOLOGY LTD
DOI: 10.1016/j.coi.2006.01.008
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Somatic hypermutation and class-switch-recombination are initiated by the deamination of deoxycytosine in DNA by activation-induced-deaminase, AID. Recently, there has been much research into how AID targets double-stranded DNA in sub-regions of Ig genes, the involvement of co-factors and posttranslational modifications in this process, the co-option of DNA 'repair' mechanisms and AID evolution.
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