Journal
ACTA PAEDIATRICA
Volume 95, Issue 4, Pages 404-406Publisher
WILEY
DOI: 10.1080/08035250500447944
Keywords
respiratory syncytial virus (RSV); congenital heart defects; hospitalization; palivizumab prophylaxis; costs
Categories
Ask authors/readers for more resources
Aims: To register hospitalizations for respiratory syncytial virus (RSV) infections and estimate costs of prophylaxis with humanized monoclonal antibodies ( palivizumab) against RSV, compared to hospital care, in cases with congenital heart defects (CHDs). Methods: Population based study with prospective registration of CHDs. Costs for hospital treatment of RSV-infections in CHD-patients calculated by means of the Norwegian Diagnosis Related Groups system. Results: In 43470 infants live born in the population through the 18-year period 1987-2004 a structural CHD was diagnosed in 527 (1.2%). A total of 898 (2.1%) hospitalizations for RSV-infections occurred in the study population 1987-2005. The hospital admittance rate was significantly higher for CHD-cases (4.8%) than for children without CHD (2%) (P = 0.002). Severe CHDs (need for surgery or catheter intervention) had a higher admittance rate (9.2%) compared to the group of remaining CHDs (3.3%) (P = 0.01). Number needed to treat with palivizumab to avoid one hospitalization for RSV-infection in cases of severe CHDs was calculated to 24, at costs of US$ 195000. The expenses for palivizuamab prophylaxis in severe CHDs were 31 times that of hospital treatment. Conclusion: Prophylaxis with palivizumab in severe CHDs is not cost-effective.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available