Journal
ARCHIVES OF TOXICOLOGY
Volume 80, Issue 4, Pages 181-186Publisher
SPRINGER HEIDELBERG
DOI: 10.1007/s00204-005-0030-8
Keywords
di(2-ethylhexyl)adipate; enhanced; TG 407; rat; endocrine effects
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We performed a 28-day repeated-dose toxicity study of di(2-ethylhexyl)adipate (DEHA) based on the draft protocol of the Enhanced OECD Test Guideline 407 to investigate whether it has endocrine-mediated properties according to this assay. DEHA was orally administered to SD rats at doses of 0, 40, 200 and 1,000 mg/kg/day for at least 28 days, and disturbance of the estrous cycle and increased ovarian follicle atresia were detected in the 1,000 mg/kg group.
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