The Treponema denticola surface protease dentilisin degrades interleukin-1β (IL-1β), IL-6, and tumor necrosis factor alpha

Dentilisin is a major surface protease and virulence factor of the bacterium Treponema denticola. In this study, we found that T. denticola reduced inflammatory cytokines, including interleukin-1 beta (IL-1 beta), IL-6, and tumor necrosis factor alpha, in peripheral blood mononuclear cells through degradation by dentilisin.