Journal
HUMAN BRAIN MAPPING
Volume 27, Issue 4, Pages 288-295Publisher
WILEY
DOI: 10.1002/hbm.20184
Keywords
fMRI; prefrontal; strategy; cognitive training
Funding
- Medical Research Council [MC_U105559859] Funding Source: researchfish
- Medical Research Council [MC_U105559859] Funding Source: Medline
- MRC [MC_U105559859] Funding Source: UKRI
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The prefrontal cortex (PFC) has been implicated in the ability to apply semantic organizational strategies during verbal encoding and episodic learning. However, there has been no direct evidence demonstrating which specific areas in the PFC are engaged after cognitive training using semantic organizational strategies in healthy adult human subjects. In this study, we investigated the effects of semantic strategic training on brain activity and changes in behavioral performance, after cognitive training, using functional MRI (fMRI). There was a significant activation in bilateral dorsolateral prefrontal (DLPF) and orbitofrontal (OFC) areas after cognitive training. These results demonstrate the engagement of bilateral DLPF and OFC cortex during strategic memory processes, particularly when mobilization and effort of effective use of strategies are required. The functional adaptations observed here may also shed light on some of the processes underlying recovery with cognitive rehabilitation in patient populations with brain injury.
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