Journal
SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY
Volume 63, Issue 5, Pages 963-969Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.saa.2005.11.015
Keywords
trace gas; infrared spectroscopy; quantum cascade laser; difference frequency generation
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We present an overview of our recent progress on spectroscopic trace gas detection for biomedical applications. The latest developments of cavity-enhanced spectroscopy as well as magnetic rotation spectroscopy lead to unprecedented sensitivity and specificity. The current detection limits of our laser spectroscopic approaches are in the picomolar to nanomolar range, depending on the molecular compound. The time resolution of the measurements is down to the sub-second range. This very high sensitivity and time resolution open up exciting perspectives for novel analytical tasks in biomedical research and clinical diagnosis. (c) 2005 Elsevier B.V. All rights reserved.
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