Journal
APPLIED AND ENVIRONMENTAL MICROBIOLOGY
Volume 72, Issue 4, Pages 3005-3010Publisher
AMER SOC MICROBIOLOGY
DOI: 10.1128/AEM.72.4.3005-3010.2006
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- NIAID NIH HHS [R01 AI 50940] Funding Source: Medline
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Soluble inhibitors find widespread applications as therapeutic drugs to reduce the ability of eukaryotic cells, bacteria, or viruses to adhere to surfaces and host tissues. Mechanical forces resulting from fluid How are often present under in vivo conditions, and it is commonly presumed that fluid flow will further add to the inhibitive effect seen under static conditions. In striking contrast, we discover that when Surface adhesion is mediated by catch bonds, whose bond life increases with increased applied force, shear stress may dramatically increase the ability of bacteria to withstand detachment by soluble competitive inhibitors. This shear stress-induced protection against inhibitor-mediated detachment is shown here for the fimbrial FimH-mannose-mediated surface adhesion of Escherichia coli. Shear stress-enhanced reduction of bacterial detachment has major physiological and therapeutic implications and needs to be considered when developing and screening drugs.
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