Journal
GENETICS
Volume 172, Issue 4, Pages 2441-2448Publisher
GENETICS SOCIETY AMERICA
DOI: 10.1534/genetics.104.040311
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Funding
- NHGRI NIH HHS [1 P50 HG002790-01A1, P50 HG002790] Funding Source: Medline
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In this article we infer the rates of gene conversion and crossing over in Arabidopsis thaliana from population genetic data. Our data set is a genomewide survey consisting of 1347 fragments of length 600 bp sequenced in 96 accessions. It has several orders of magnitude more markets than any previous nonhuman study. This allows for more accurate inference as well as a detailed comparison between theoretical expectations and observations. Our methodology is specifically set to account for deviations such as recurrent mutations or a skewed frequency spectrum. We found that even if some components of the model clearly do not fit, the pattern of LD conforms to theoretical expectations quite well. The ratio of gene conversion to crossing over is estimated to be around one. We also find evidence for fine-scale variations of the crossing-over rate.
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