Journal
ANNALS OF SURGERY
Volume 259, Issue 4, Pages 642-648Publisher
LIPPINCOTT WILLIAMS & WILKINS
DOI: 10.1097/SLA.0000000000000361
Keywords
epigenetics; genetics; metabolic thrift; obesity; thrifty genotype; thrifty phenotype
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Funding
- National Institutes of Health [K08DK074397, R03DK095050, R01DK097449]
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Evolution has molded metabolic thrift within humans, a genetic heritage that, when thrust into our modern obesogenic environment, creates the current obesity crisis. Modern genetic analysis has identified genetic and epigenetic contributors to obesity, an understanding of which will guide the development of environmental, pharmacologic, and genetic therapeutic interventions.
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