4.3 Review

Androgens, aging, and Alzheimer's disease

Journal

ENDOCRINE
Volume 29, Issue 2, Pages 233-241

Publisher

SPRINGER
DOI: 10.1385/ENDO:29:2:233

Keywords

testosterone; Alzheimer's disease; beta-amyloid; neuroprotection; dihydrotestosterone; luteinizing hormone

Funding

  1. NIA NIH HHS [AG23739] Funding Source: Medline

Ask authors/readers for more resources

Testosterone depletion is a normal consequence of aging in men that is associated with senescent effects in androgen-responsive tissues. We discuss new evidence that one consequence of testosterone depletion in men is an increased risk for the development of Alzheimer's disease (AD). Furthermore, we discuss two candidate mechanisms by which testosterone may affect AD pathogenesis. First, testosterone has been identified as an endogenous regulator of beta-amyloid, a protein that abnormally accumulates in AD brain and is implicated as a causal factor in the disease. Second, findings from several different paradigms indicate that testosterone has both neurotrophic and neuroprotective functions. These new findings support the clinical evaluation of androgen-based therapies for the prevention and treatment of AD.

Authors

I am an author on this paper
Click your name to claim this paper and add it to your profile.

Reviews

Primary Rating

4.3
Not enough ratings

Secondary Ratings

Novelty
-
Significance
-
Scientific rigor
-
Rate this paper

Recommended

No Data Available
No Data Available