Journal
NATURE BIOTECHNOLOGY
Volume 24, Issue 4, Pages 437-438Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/nbt1199
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Implanted drug delivery systems are being increasingly used to realize the therapeutic potential of peptides and proteins. Here we describe the controlled pulsatile release of the polypeptide leuprolide from microchip implants over 6 months in dogs. Each microchip contains an array of discrete reservoirs from which dose delivery can be controlled by telemetry.
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