Journal
ONCOLOGIST
Volume 11, Issue 4, Pages 342-357Publisher
ALPHAMED PRESS
DOI: 10.1634/theoncologist.11-4-342
Keywords
chemotherapy; apoptosis; necrosis; autophagy; senescence; mitotic catastrophe
Categories
Funding
- NCI NIH HHS [K01 CA098092-05, K01 CA098092-01A2, K01 CA098092, K01 CA098092-02, K01 CA098092-06, K01 CA098092-03, K01 CA098092-04] Funding Source: Medline
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For several decades, apoptosis has taken center stage as the principal mechanism of programmed cell death in mammalian tissues. It also has been increasingly noted that conventional chemotherapeutic agents not only elicit apoptosis but other forms of nonapoptotic death such as necrosis, autophagy, mitotic catastrophe, and senescence. This review presents background on the signaling pathways involved in the different cell death outcomes. A re-examination of what we know about chemotherapy-induced death is vitally important in light of new understanding of nonapoptotic cell death signaling pathways. If we can precisely activate or inhibit molecules that mediate the diversity of cell death outcomes, perhaps we can succeed in more effective and less toxic chemotherapeutic regimens.
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