Journal
JOURNAL OF MAMMARY GLAND BIOLOGY AND NEOPLASIA
Volume 11, Issue 2, Pages 151-163Publisher
SPRINGER/PLENUM PUBLISHERS
DOI: 10.1007/s10911-006-9021-5
Keywords
intravital imaging; GFP; real-time imaging; breast cancer; second harmonic generation
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Funding
- NCI NIH HHS [CA100324] Funding Source: Medline
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Advances in optical imaging technologies that allow the subcellular resolution of undissected tissue have begun to offer new clues into the biology of development and disease. For cancer, such advances mean that the primary tumor is no longer a black box and that the disease can be studied throughout the metastatic cascade and not just as an endpoint. In this review we examine the advances in multiphoton imaging technology that have been used to define the microenvironment and its role in delineating the invasion and intravasation steps of metastasis inside living mammary tumors. Results show that the tumor microenvironment is a dynamic place where interactions between tumor cells, macrophages, blood vessels, and extracellular matrix fibers define the metastatic phenotype.
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