Immunohistochemical prognostic factors in resected colorectal lung metastases using tissue microarray analysis

Aims: Immunohistochemical prognostic factors of pulmonary metastatic colorectal cancer lesions have not been well investigated. The study was conducted to identify the immunohistochemical prognostic factors of metastasized colorectal cancer. Methods: We immunohistochemicaly investigated the expression of insulin-like growth factor-1 receptor (IGFI-R), E-cadherin, beta-catenin, and p53 using a tissue microarray in the surgical specimens of 86 metastatic lesions. Results: The univariate analysis revealed E-cadherin and membrane beta-catenin positive to be prognostic factors. IGFI-R and p53 were not significantly associated with the patient's survival. In multivariate analysis, the reduced expression of E-cadherin, aerogenous spread with floating cancer cell clusters and vascular invasion were independent prognostic factors. Conclusions: The reduced expression of E-cadherin in the pulmonary metastatic lesions was an independent predictor of poor survival after pulmonary metastasectomy. (c) 2005 Published by Elsevier Ltd.