Journal
JOURNAL OF IMMUNOASSAY & IMMUNOCHEMISTRY
Volume 27, Issue 2, Pages 195-205Publisher
TAYLOR & FRANCIS INC
DOI: 10.1080/15321810600595443
Keywords
cyclosporine A; tacrolimus; peripheral blood mononuclear cells; 3-( 4,5-dimethylthiazol-2-yl)-2,5; diphenyl tetrazolium bromide (MTT); lymphocyte immunosuppressant sensitivity test (LIST)
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The dose of calcineurin inhibitors in renal transplantation has been adjusted, based on the therapeutic drug monitoring data. However, the data do not always correlate with clinical drug efficacy. In vitro response of peripheral-blood mononuclear cells to immunosuppressive drugs is reported to correlate with the recipient-response to therapeutic efficacy of the drug. We report, here, usefulness of a lymphocyte immunosuppressant sensitivity test for the estimation of individual drug sensitivity in renal transplant recipients. The LIST we have developed includes MTT assay procedures without the use of radioisotope-labeled compounds, which is convenient for general hospital use. Utilizing this procedure, we compared the pharmacological efficacy between cyclosporine A and tacrolimus in 41 renal transplant recipients.
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