Journal
ANALYTICAL AND BIOANALYTICAL CHEMISTRY
Volume 384, Issue 7-8, Pages 1501-1505Publisher
SPRINGER HEIDELBERG
DOI: 10.1007/s00216-006-0352-2
Keywords
nonsteroidal anti-inflammatory drugs; liquid chromatography-mass spectrometry; solid-phase extraction; human plasma
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A rapid, selective and sensitive analytical method for the simultaneous determination of 16 nonsteroidal anti-inflammatory drugs (NSAIDs) in human plasma was carried out using Oasis HLB solid-phase extraction (SPE), followed by reversed-phase high-performance liquid chromatography and quadrupole mass spectrometry with electrospray ionization operated in the negative ion mode. The recoveries of NSAIDs from human plasma by SPE were greater than 76.7%. The use of a short column packed with small particles enabled rapid and simultaneous determination within 7 min. The detection limits for the NSAIDs were 0.01-0.9 mu g/ml using the selected ion monitoring mode.
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