Journal
EUROPEAN JOURNAL OF CANCER
Volume 42, Issue 6, Pages 768-778Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.ejca.2006.01.006
Keywords
CXC chemokines; angiogenesis; angiostasis; tumourigenesis; cancer
Categories
Funding
- NCI NIH HHS [P50 CA 90388, CA 87879] Funding Source: Medline
- NHLBI NIH HHS [P50 HL 67665, HL 66027, HL 03906, HL 04493] Funding Source: Medline
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Chemokines have pleiotropic effects in regulating immunity, angiogenesis, stem cell trafficking, and mediating organ-specific metastases of cancer. In the context of angiogenesis, the CXC chemokine family is a unique group of cytokines known for their ability to behave in a disparate manner in the regulation of angiogenesis. The glutamic acid-leucine-arginine (ELR+) CXC chemokines are potent promoters of angiogenesis, and mediate their angiogenic activity via signal-coupling of CXCR2 on endothelium. By contrast, members of the CXC chemokine family, such as platelet factor-4 (PF4; CXCL4) and interferon-inducible CXC chemokines are potent inhibitors of angiogenesis, and use CXCR3 on endothelium to mediate their angiostatic activity. This review will discuss the biology of CXC chemokines in the context of angiogenesis related to cancer. (c) 2006 Elsevier Ltd. All rights reserved.
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