Calciuria and preeclampsia:: A case-control study

Objective: The aim of this study was to compare calciuria of preeclamptic cases to normotensive controls among pregnant women hospitalized in the French West Indies obstetrics department. Study design: This case-control study included 47 preeclamptic women and 50 controls. The main outcome was 24 h urinary calcium excretion rate. Serum levels of creatinine, calcium and uric acid were also analyzed. A logistic regression analysis has been performed to investigate the relationship between hypocalciuria and preeclampsia after having taken into account prognostic preeclampsia factors and pertinent clinical criteria. Results: Women with preeclampsia had significantly lower calciuria than normotensive patients (1.5 mmol/24 +/- 1.0 versus 6.0 mmol/24 +/- 4.2, p = 0.0001). After taking into account gestational age at hospitalization, body mass index and nulliparity, hypocalciuria was significantly associated with preeclampsia (ORa = 21.74; 95% Cl, 6.9-66.7). The diagnosis value of a calciuria less than 2.1 mmol/24 h is interesting because of its negative predictive value (97%), but its positive predictive value is weak (42%). Conclusion: In our population, precclamptic women had a calciuria significantly lower than controls. (c) 2005 Published by Elsevier Ireland Ltd.