Journal
NEUROSCIENTIST
Volume 12, Issue 2, Pages 102-106Publisher
SAGE PUBLICATIONS INC
DOI: 10.1177/1073858405281673
Keywords
cerebral cortex; development; axonal branching; neural activity; organotypic culture; glutamate receptors
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Axonal branching is an important process for establishing the final pattern of connections between a neuron and its target cells. Cortical connections between upper-layer cells in the neocortex have provided insights into the cellular mechanisms by which electrical activity regulates neural connectivity, including branch formation. Recent evidence further indicates that spontaneous firing and synaptic transmission contribute to axonal branching of cortical neurons through postsynaptic activation.
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