Journal
PIGMENT CELL RESEARCH
Volume 19, Issue 2, Pages 112-124Publisher
WILEY
DOI: 10.1111/j.1600-0749.2006.00304.x
Keywords
NF-kappa B; IKK; melanoma; MAP3K; cytokines; apoptosis
Categories
Funding
- NCI NIH HHS [CA 098807, T32 CA009592, R01 CA116021-01, CA 116021, R01 CA116021, R01 CA098807, R01 CA116021-03, R01 CA116021-02] Funding Source: Medline
- BLRD VA [IK6 BX005225] Funding Source: Medline
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Metastatic melanoma is an aggressive skin cancer that is notoriously resistant to current cancer therapies. In human melanoma, nuclear factor-kappa B (NF-kappa B) is upregulated, leading to the deregulation of gene transcription. In this review, we discuss (i) the relationship between gene alteration in melanoma and upregulation of NF-kappa B, (ii) mechanisms by which activated NF-kappa B switch from pro-apoptotic to anti-apoptotic functions in melanoma and (iii) autocrine mechanisms that promote constitutive activation of NF-kappa B in metastatic melanoma.
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