Journal
MICROBES AND INFECTION
Volume 8, Issue 4, Pages 1167-1173Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.micinf.2005.10.032
Keywords
Mycobacterium; Salmonella; interleukin-12; interleukin-23; interleukin-12/23R beta 1; mutation
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Interleukin (IL)-12/IL-23 signal transduction-deficient individuals with genetic defects in IL12RB1 or IL12B often suffer from unusual mycobacterial and Salmonella infections. Here we discuss recent questions that have arisen from clinical observations that cast doubt on the necessity of IL-12/IL-23 signaling in controlling infections with intracellular bacteria. Alternative IL-12/IL-23-dependent, interferon-gamma-independent pathways of immunity to intracellular bacteria are also discussed. (c) 2005 Elsevier SAS. All rights reserved.
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