Journal
JOURNAL OF NEUROIMMUNOLOGY
Volume 173, Issue 1-2, Pages 117-125Publisher
ELSEVIER
DOI: 10.1016/j.jneuroim.2005.12.009
Keywords
corticotrope cells; stress; alternative splicing; neuroimmunomodulation; proinflammatory cytokine
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The present study investigated the expression of IL-18 mRNA under several stimuli, and molecular structures of IL-18 mRNA of the rat pituitary. Real-time PCR demonstrated that IL-18 mRNA, highly expressed in anterior pituitary, significantly increased following stress and adrenalectomy. In situ hybridization combined with immunohistochemistry demonstrated that corticotrope cells expressed IL-18 mRNA. RACE and sequence analysis demonstrated that pituitary IL-18 mRNA possesses five newexons at the upstream of exon 1 and between exon 1 and exon 2, indicating the preferential usage of promoter 1. The present study Suggests that IL-18 in the corticotrope cells may play some roles in stress responses. (c) 2005 Elsevier B.V. All rights reserved.
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