Journal
BEHAVIORAL NEUROSCIENCE
Volume 120, Issue 2, Pages 324-336Publisher
AMER PSYCHOLOGICAL ASSOC
DOI: 10.1037/0735-7044.120.2.324
Keywords
conditioned fear; anxiety; bed nucleus of the stria terminalis; behavior systems
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Funding
- NIMH NIH HHS [R01 MH064847, R01 MH64847] Funding Source: Medline
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Four experiments investigated the effects of lesions of the bed nucleus of the stria terminalis (BLAST) on conditioned fear and anxiety. Though BLAST lesions did not disrupt fear conditioning with a short-duration conditional stimulus (CS; Experiments 1 and 3), the lesion attenuated conditioning with a longer duration CS (Experiments 1 and 2). Experiment 3 found that lesions attenuated reinstatement of extinguished fear, which relies on contextual conditioning. Experiment 4 confirmed that the lesion reduced unconditioned anxiety in an elevated zero maze. The authors suggest that long-duration CSs, whether explicit cues or contexts, evoke anxiety conditioned responses, which are dissociable from fear responses to shorter CSs. Results are consistent with behavioral and anatomical distinctions between fear and anxiety and with a behavior-systems view of defensive conditioning.
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