Journal
JOURNAL OF CLINICAL MICROBIOLOGY
Volume 44, Issue 4, Pages 1571-1574Publisher
AMER SOC MICROBIOLOGY
DOI: 10.1128/JCM.44.4.1571-1574.2006
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- Wellcome Trust [051350/Z, 059040] Funding Source: Medline
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Six immunocompetent patients with human herpesvirus 6 (HHV-6) chromosomal integration had HHV-6 and beta-globin DNA quantified in various samples by PCR. The mean HHV-6 DNA concentration (log(10) copies/milliliter) in blood was 7.0 (>= 1 HHV-6 DNA copies/leukocyte), and in serum it was 5.3 (>= 1 HHV-6 DNA copies/lysed cell). The mean HHV-6 DNA load (log(10) copies)/hair follicle was 4.2 (>= 1 copies/hair follicle cell), demonstrating that viral integration is not confined to blood cells. The characteristically high HHV-6 DNA levels in chromosomal integration may confound laboratory diagnosis of HHV-6 infection and should be given due consideration.
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