Journal
TRANSFUSION MEDICINE
Volume 16, Issue 2, Pages 79-83Publisher
BLACKWELL PUBLISHING
DOI: 10.1111/j.1365-3148.2006.00652.x
Keywords
hepatitis E; 'post-donation illness'; 'transfusion-transmitted infection'
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Indigenous hepatitis E is increasingly recognized in developed countries, where it may be a zoonosis. We describe the first case of transfusion-transmitted hepatitis E in the UK from a blood donor who had no history of recent travel abroad. Follow-up of the donor and recipients of the blood products was carried out using serological and molecular techniques. Acute hepatitis E was transmitted to one of two recipients. The infected patient would have received a larger volume of the donor's plasma. HEV subgenomic sequences carried by the donor and recipient were identical. This is the first case of post-transfusion hepatitis E in the UK. Secondary transmission of hepatitis E indigenous to a nonhyperendemic country may occur by blood transfusion. It is important that blood donors inform the transfusion service of all post-donation illnesses so that appropriate interventions can take place.
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