Journal
ACTA PHARMACOLOGICA SINICA
Volume 27, Issue 4, Pages 387-394Publisher
ACTA PHARMACOLOGICA SINICA
DOI: 10.1111/j.1745-7254.2006.00315.x
Keywords
SRC-3/AIB1; oncogene; mouse model; cancer; signal transduction
Funding
- NCI NIH HHS [CA58204] Funding Source: Medline
- NIDDK NIH HHS [U01DK63 424] Funding Source: Medline
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Steroid receptor coactivator-3 (SRC-3, also known as NCoA3, AIB1, p/CIP, RAC3, ACTR, and TRAM1), localized on a frequently amplified region, 20q12, has been associated with multiple cancers, including breast, gastric and prostate cancers. Although SRC-3 has been implicated as an oncogene, compelling evidence has only recently emerged implicating it as a causal factor in the genesis of human cancers. Here, we summarize recent evidence that indicates aberrant SRC-3 expression is important in hormone-sensitive and -insensitive human cancers.
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