Journal
EUROPEAN JOURNAL OF CELL BIOLOGY
Volume 85, Issue 3-4, Pages 213-218Publisher
ELSEVIER GMBH, URBAN & FISCHER VERLAG
DOI: 10.1016/j.ejcb.2005.10.004
Keywords
invadopodia; podosomes; carcinoma; macrophage; WASP; N-WASP; invasion; metastasis; EGF; CSF-1
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Funding
- NCI NIH HHS [CA100324] Funding Source: Medline
- NIGMS NIH HHS [R01 GM038511, GM38511] Funding Source: Medline
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Cell migration through the extracellular matrix (ECM) is necessary for cancer cells to invade adjacent tissues and metastasize to an organ distant from primary tumors. Highly invasive carcinoma cells form ECM-degradingy membrane protrusions called invadopodia. Tumor-associated macropliages have been shown to promote the migratory phenotypes of carcinoma cells, and macrophages are known to form podosomes, similar structures to invadopodia. However, the role of invadopodia and podosomes in vivo remains to be determined. In this paper, we propose a model for possible functions and interactions of invadopodia and podosomes in tumor invasion, based on observations that macrophage podosomes degrade ECM and that podosome formation is regulated by colony-stimulating factor-l signaling. Published by Elsevier GmbH.
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