Journal
JOURNAL OF BACTERIOLOGY
Volume 188, Issue 7, Pages 2711-2714Publisher
AMER SOC MICROBIOLOGY
DOI: 10.1128/JB.188.7.2711-2714.2006
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Funding
- NIAID NIH HHS [R01 AI057472, AI057472] Funding Source: Medline
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We have cloned a lytic enzyme, PlyPH, with a specific lytic effect on Bacillus anthracis strains. PlyPH remains active between pH 4 and 10.5, and a single dose rescued a significant percentage of mice infected intraperitoneally with an attenuated B. anthracis strain. We propose PlyPH as a novel therapeutic agent.
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