Journal
NEUROCHEMICAL RESEARCH
Volume 31, Issue 4, Pages 579-584Publisher
SPRINGER/PLENUM PUBLISHERS
DOI: 10.1007/s11064-006-9049-3
Keywords
glia maturation factor; brain-derived neurotrophic factor; exercise; neuroprotection; gene knockout; real-time PCR
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Funding
- NINDS NIH HHS [NS-47145] Funding Source: Medline
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We earlier reported that overexpression of glia maturation factor (GMF) in cultured astrocytes enhances the production of brain-derived neurotrophic factor (BDNF). The current study was conducted to find out whether BDNF production is impaired in animals devoid of GMF. To this end GMF-knockout (KO) mice were subjected to exercise and the neurotrophin mRNAs were determined by real-time RT-PCR. Compared to wild-type (WT) mice, there is a decrease in exercise-induced BDNF in the KO mice. The observation was correlated with the finding that, in WT mice, exercise increases GMF expression. The results are consistent with the hypothesis that GMF is necessary for exercise-induction of BDNF, and that GMF may promote neuroprotection through BDNF production.
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