Journal
BIOTECHNOLOGY LETTERS
Volume 28, Issue 8, Pages 555-558Publisher
SPRINGER
DOI: 10.1007/s10529-006-0018-3
Keywords
asymmetric; chiral; organic solvents; sulfoxidation
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Funding
- NIGMS NIH HHS [R01-GM66712] Funding Source: Medline
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The impact of co-lyophilizing horseradish peroxidase (HRP) with numerous amino acids and other chiral excipients on the enzyme's subsequent stereoselectivity [E(S/R)] in the sulfoxidation of thioanisole in 2-propanol was systematically investigated. While many improved the stereoselectivity of (and significantly activated) HRP, the greatest effect was observed with D-proline which enhanced the E(S/R) value by over an order of magnitude from synthetically meaningless to useful.
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