Journal
MACROMOLECULAR RAPID COMMUNICATIONS
Volume 27, Issue 7, Pages 548-552Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/marc.200500876
Keywords
biomimetic; chitosan; long-circulating macromolecular drug delivery (LCMDD); phosphorylcholine
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Water-soluble biomimetic chitosan derivative conjugating zwitterionic phosphorylcholine was efficiently prepared through Atherton-Todd reaction under the mild conditions, and the possible formation mechanism of zwitterionic product was related to the nucleophilic attack of adjacent 3-hydroxyl on the D-glucosamine residue to phosphorus with the help of base. UV absorption and melting behaviors of DNA/phosphorylcholine-bound chitosan derivative showed that the phosphorylcholine-bound chitosan derivative could be a new carrier for long-circulating macromolecular drug delivery.
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