Journal
TETRAHEDRON LETTERS
Volume 47, Issue 14, Pages 2391-2393Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.tetlet.2006.01.149
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A novel one-pot-synthesis of highly substituted indol-2-ones using a combination of Ugi and Fleck reaction (U-4CR-Heck) is described. The synthesized indol-2-ones represent an interesting pharmacological scaffold with Four potential points of diversity. Thus, this novel reaction-type is amenable to combinatorial high-throughput screening. (c) 2006 Elsevier Ltd. All rights reserved.
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