Journal
NEUROREPORT
Volume 17, Issue 5, Pages 541-544Publisher
LIPPINCOTT WILLIAMS & WILKINS
DOI: 10.1097/01.wnr.0000208995.38695.2f
Keywords
development; juvenile mouse behavior; Rett syndrome; somatosensory reflexes; ultrasonic vocalization
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Funding
- PHS HHS [0F14, 5 R44 NSO 34591-01] Funding Source: Medline
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We examined somatic growth, somatosensory reflexes, and ultrasonic calls from postnatal day 3 to day 18 in Mecp2(llox) mutant mice, a mouse model of Rett syndrome. Both Mecp2 null male and Mecp2 heterozygous female mice exhibited normal somatic growth, but transient delays in the development of some reflexes relative to sex-matched wild-type mice. Both Mecp2 null male and heterozygous female mice exhibited dramatic increases in ultrasonic vocalizations in response to social isolation; these differences were evident as early as postnatal day 5. These results suggest very early abnormalities in sensory reflex development and behavioral responsiveness in the Mecp2 mutants that may provide a target for early therapeutic intervention. NeuroReport 17:541-544 (c) 2006 Lippincott Williams& Wilkins.
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