Journal
FEBS LETTERS
Volume 580, Issue 8, Pages 2123-2128Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.febslet.2006.02.080
Keywords
guanylate cyclase; nitric oxide; cirrhosis; quantitative cytochemistry
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The production of nitric oxide (NO) in liver disease and its role in vascular control has been a subject of much interest in recent years. However, the activity of guanylate cyclase (GC), the enzyme activated by NO has received little attention with regard to liver disease. In this study we have utilised a quantitative cytochemical technique to examine the activity of GC on a per cell basis in a rat model of cirrhosis. Our results show a significant reduction in GC activity, indicating that vascular regulation is likely to be substantially affected irrespective of NO generation in this disease model. (c) 2006 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.
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