Journal
JOURNAL OF MEDICINAL CHEMISTRY
Volume 49, Issue 7, Pages 2151-2154Publisher
AMER CHEMICAL SOC
DOI: 10.1021/jm060029z
Keywords
-
Categories
Funding
- NIGMS NIH HHS [GM71630, R01 GM071630] Funding Source: Medline
Ask authors/readers for more resources
Screening in Mixtures is a common approach for increasing the efficiency of high-throughput screening. Here we investigate how the compound load of mixtures influences promiscuous aggregate-based inhibition. We screened 764 molecules individually and in mixtures of 10 at 5 mu M each, comparing the observed inhibition of the mixtures to that predicted from single-compound results. Synergistic effects on aggregation predominated, although antagonism was also observed. These results suggest that screening mixtures can increase aggregation-based inhibition in a nonadditive manner.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available