Journal
PHYSICS IN MEDICINE AND BIOLOGY
Volume 51, Issue 7, Pages 1649-1659Publisher
IOP PUBLISHING LTD
DOI: 10.1088/0031-9155/51/7/001
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Monitoring cell profiles in 3D porous scaffolds presents a major challenge in tissue engineering. In this study, we investigate optical coherence tomography (OCT) as an imaging modality to monitor non-invasively both structures and cells in engineered tissue constructs. We employ time-domain OCT to visualize macro-structural morphology, and whole-field optical coherence microscopy to delineate the morphology of cells and constructs in a developing in vitro engineered bone tissue. The results show great potential for the use of OCT in non-invasive monitoring of cellular activities in 3D developing engineered tissues.
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