Journal
SCIENCE
Volume 312, Issue 5770, Pages 114-116Publisher
AMER ASSOC ADVANCEMENT SCIENCE
DOI: 10.1126/science.1124228
Keywords
-
Categories
Funding
- NCI NIH HHS [T32 CA009138] Funding Source: Medline
- NIAID NIH HHS [AI27998, T32-AI007313, F32 AI063793, F32 AI063793-01A1, AI39614] Funding Source: Medline
Ask authors/readers for more resources
Immunity to a plethora of microbes depends on a diverse repertoire of naive lymphocytes and the production of long-lived memory cells. We present evidence here that low clonal abundance in a polyclonal repertoire favors the survival and activation of naive CD4(+) T cells as well as the survival of their memory cell progeny. The inverse relation between clonal frequency and survival suggests that intraclonal competition could help maintain an optimally diverse repertoire of T cells and an optimal environment for the generation of long-lived memory cells.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available