Journal
NEUROSCIENCE LETTERS
Volume 397, Issue 1-2, Pages 145-148Publisher
ELSEVIER IRELAND LTD
DOI: 10.1016/j.neulet.2005.12.029
Keywords
CXCL16; CCL18; CCL17; chemokines-cerebrospinal fluid; systemic lupus erythematosus (SLE)
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In neuro-inflammatory diseases, activated T cells are thought to drive the inflammatory process. In this study, we investigated the potential role of three T cell attracting chemokines (CK) in neuro-inflammation. For this purpose, we measured levels of CXCL 16, CCL17 and CCL18 in matched serum and cerebrospinal fluid (CSF) samples of patients with different neurological diseases. Interestingly, CXCL16 levels were significantly elevated in the CSF and were higher in inflammatory disease than in controls, whereas CCL17 and CCL18 were absent in the CSF. CCL18 was only elevated in serum of SLE patients. These data suggest that attraction of activated memory type T cells by CXCL16 might play an important role in the orchestration of immune responses in the central nervous system. (C) 2005 Elsevier Ireland Ltd. All rights reserved.
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