4.4 Article

Two-step synthesis of the bipyrrole precursor of prodigiosins

Journal

TETRAHEDRON LETTERS
Volume 47, Issue 15, Pages 2605-2606

Publisher

PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.tetlet.2006.02.035

Keywords

natural product; prodigiosins; tambjamines; haloformylation; bipyrrole; Suzuki coupling

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The key intermediate in the synthesis of prodigiosins, 4-methoxy-2,2'-bipyrrole-5-carboxaldehyde, has been prepared in two steps and 65% overall yield from the commercially available 4-methoxy-3-pyrrolin-2-one. (c) 2006 Elsevier Ltd. All rights reserved.

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