Journal
ORGANIC LETTERS
Volume 8, Issue 8, Pages 1745-1747Publisher
AMER CHEMICAL SOC
DOI: 10.1021/ol060485h
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Funding
- NIGMS NIH HHS [GM069559, R01 GM069559] Funding Source: Medline
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The syntheses of two biologically active molecules possessing dihydropyrroloindole cores (1 and 2) were completed using rhodium-catalyzed imine-directed CA bond functionalization, with the second of these molecules containing a stereocenter that can be set with 90% ee during cyclization using chiral nonracemic phosphoramidite ligands. Catalytic decarbonylation and direct indole/maleimide coupling provide efficient access to 2.
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