Journal
SCIENCE
Volume 312, Issue 5771, Pages 279-283Publisher
AMER ASSOC ADVANCEMENT SCIENCE
DOI: 10.1126/science.1124779
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Funding
- NCI NIH HHS [CA87969] Funding Source: Medline
- NHLBI NIH HHS [R01HL54485, U01 HL065899, R01HL66289, R01HL074166, U01HL65899] Funding Source: Medline
- NICHD NIH HHS [R01 HD060726] Funding Source: Medline
- NIDDK NIH HHS [K23DK067288, P30DK46200] Funding Source: Medline
- NIGMS NIH HHS [R01GM046877] Funding Source: Medline
- NIMH NIH HHS [R01MH59532] Funding Source: Medline
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Obesity is a heritable trait and a risk factor for many common diseases such as type 2 diabetes, heart disease, and hypertension. We used a dense whole-genome scan of DNA samples from the Framingham Heart Study participants to identify a common genetic variant near the INSIG2 gene associated with obesity. We have replicated the finding in four separate samples composed of individuals of Western European ancestry, African Americans, and children. The obesity-predisposing genotype is present in 10% of individuals. Our study suggests that common genetic polymorphisms are important determinants of obesity.
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