Journal
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
Volume 16, Issue 8, Pages 2189-2194Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.bmcl.2006.01.047
Keywords
excitatory amino acid receptors; KA receptor agonist; KA reeptor antagonist; NMDA receptor agonist; dysiherbaine; scaffold
Categories
Funding
- NIGMS NIH HHS [GM07311] Funding Source: Medline
- NINDS NIH HHS [R01 NS027600, NS-27600] Funding Source: Medline
Ask authors/readers for more resources
The design and synthesis of four 2,2-disubstituted dihydrobenzofurans that are structurally related to several glutamate-containing natural products, including (-)-dysiherbaine, is described. Biological evaluation of these analogs shows that one is a KA receptor antagonist and another is an NMDA receptor agonist. (C) 2006 Elsevier Ltd. All rights reserved.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available
Share Paper
