Journal
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
Volume 16, Issue 8, Pages 2109-2112Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.bmcl.2006.01.066
Keywords
AIDS; HIV; reverse transcriptase; inhibitor; oxindole; heterocycle; SAR
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A series of heterocycle-containing oxindoles was synthesized and their HIV antiviral activities were assessed. Some of these analogs exhibited potent inhibitory activities against both wild-type virus and a number of drug-resistant Mutant viruses. In addition, oxindole 9z also showed promising pharmacokinetics. (C) 2006 Elsevier Ltd. All rights reserved.
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