Journal
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
Volume 16, Issue 8, Pages 2234-2237Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.bmcl.2006.01.045
Keywords
antiinflammatory; antioxidant; thiazoline; copper complexes
Categories
Ask authors/readers for more resources
A new series of complexes of the type [Cu(dien)(2a-2tzn)Y-2] and [Cu(dienXX)(2a-2tzn)Y-2] has been tested for anti-inflammatory and antioxidant activity. The tested compounds inhibit significantly the carrageenin induced paw edema (36.4-55.8%) and present important scavenging activities. Although their interaction with the free stable radical DPPH is not high they proxide anions. Compound 7 is the most potent (55.8%) in the in vivo experiment. Lipophilicity-as R-M values and theoretically calculated log P values-has been determined. Ail attempt to correlate the biological results with their structural characteristics and physicochemical parameters has been done. (C) 2006 Elsevier Ltd. All rights reserved.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available