Journal
JOURNAL OF IMMUNOLOGY
Volume 176, Issue 8, Pages 4959-4967Publisher
AMER ASSOC IMMUNOLOGISTS
DOI: 10.4049/jimmunol.176.8.4959
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Funding
- NIAID NIH HHS [R01 AI40618-08S1, R01 AI40618-08, K08 AI049957] Funding Source: Medline
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Th1 and Th2 effector CD4(+) T cells orchestrate distinct counterregulatory biological responses. To deliver effective tissue Th1- and Th2-type responses, Th1 and Th2 cell recruitment into tissue must be differentially regulated. We show that tissue-derived STAT1 controls the trafficking of adoptively transferred, Ag-specific, wild-type Th1 cells into the lung. Trafficking of Th1 and Th2 cells is differentially regulated as STAT6, which regulates Th2 cell trafficking, had no effect on the trafficking of Th1 cells and STAT1 deficiency did not alter Th2 cell trafficking. We demonstrate that STAT1 control of Thl cell trafficking is not mediated through T-bet. STAT1 controls the recruitment of Th1cells through the induction of CXCL9, CXCL10, CXCL11, and CXCL16, whose expression levels in the lung were markedly decreased in STAT1(-/-) mice. CXCL10 replacement partially restored Th1 cell trafficking in STAT1-deficient mice in vivo, and deficiency in CXCR3, the receptor for CXCL9, CXCL10, and CXCL11, impaired the trafficking of adoptively transferred Thl cells in wild-type mice. Our work identifies that STAT1 in peripheral tissue regulates the homing of Ag-specific Thl cells through the induction of a distinct subset of chemokines and establishes that Th1 and Th2 cell trafficking is differentially controlled in vivo by STAT1 and STAT6, respectively.
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