Journal
IMMUNOLOGY LETTERS
Volume 104, Issue 1-2, Pages 76-82Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.imlet.2005.11.017
Keywords
adaptor protein; membrane receptors; signaling; tyrosine phosphorylation
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The Grb2 associated binder (Gab) adaptor/scaffolding protein family comprises conserved proteins: mammalian Gab1, Gab2 and Gab3, Drosophila Dos and Caenorhabditis elegans Soc1. Gab adaptors are involved in multiple signaling pathways mediated by receptor- and nonreceptor protein tyrosine kinases (PTKs), and become phosphorylated upon stimulation by growth factors-, cytokines-, IQ Fc- and antigen receptors. Through its phosphorylated tyrosine containing motifs, proline-rich sequences and pleckstrin homologue (PH) domain Gab adaptors may generate an interacting platform for proteins with SH2 and SH3 domains and may transfer these molecules to the plasma membrane, thereby contributing to their activation. This review will concentrate on the function of mammalian Gab proteins in the signal transduction triggered by immune receptors. (C) 2005 Elsevier B.V. All rights reserved.
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