Journal
OPTICS LETTERS
Volume 31, Issue 8, Pages 1079-1081Publisher
OPTICAL SOC AMER
DOI: 10.1364/OL.31.001079
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Funding
- NIBIB NIH HHS [1 R01 EB001777, 1 R01 EB00108] Funding Source: Medline
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The spectroscopic content within optical coherence tomography (OCT) data can provide a wealth of information. Spectroscopic OCT methods are frequently limited by time-frequency trade-offs that limit high spectral and spatial resolution simultaneously. We present spectroscopic spectral-domain optical coherence microscopy performed with a multimodality microscope. Restricting the spatial extent of the signal by using high-numerical-aperture optics makes high-resolution spectroscopic information accessible, facilitated with spectral-domain detection. Simultaneous acquisition of multiphoton microscopy images is used to validate tissue structure and localization of nuclei within individual cells. (c) 2006 Optical Society of America.
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